Home/Programs/GLP-1 Metabolic Program
GLP-1 · Semaglutide · Tirzepatide

The weight management program
that starts with your health, not a prescription.

Clinician-supervised metabolic program — labs included, full titration support, and ongoing care. Compound semaglutide and tirzepatide from $249/month. No prior authorization. No insurance required.

Section 1

Is This Program Right For You?

This program is designed for people who:

  • Have a BMI of 27 or higher, or BMI 25+ with a weight-related health condition (hypertension, type 2 diabetes, sleep apnea)
  • Have struggled with sustained weight loss through diet and exercise alone
  • Want clinician-supervised support for insulin resistance or metabolic syndrome
  • Are seeking cardiovascular risk reduction alongside weight management
  • Are adults aged 18–74 in any U.S. state

This program may NOT be appropriate if:

  • You have a personal or family history of medullary thyroid carcinoma (MTC) or MEN2 syndrome
  • You have a history of pancreatitis
  • You are pregnant, planning pregnancy, or breastfeeding
  • You have severe gastrointestinal disease
  • You have type 1 diabetes or a history of diabetic ketoacidosis

Your clinician will make the final determination during your consultation. The criteria above are guidelines, not absolutes.

Section 2

What's Included

🩺

Clinician Consultation

Initial evaluation of your health history, goals, and contraindications. Monthly async check-ins to assess response and adjust your protocol.

🔬

Lab Work & Monitoring

Baseline labs ordered at start. Quarterly monitoring of relevant metabolic markers. Your clinician reviews results and adjusts accordingly.

💊

Medication (If Prescribed)

Compound semaglutide or tirzepatide — injections or oral formulations — prescribed only if your clinician determines it's clinically appropriate.

📋

Lifestyle Support Plan

Nutrition principles, movement guidelines, and sleep protocols tailored to support and extend GLP-1 outcomes — designed by your care team.

📈

Progress Tracking

Monthly weight, energy, and symptom check-ins via the patient portal. Lab trends visualized over time so you can see what's working.

💬

Ongoing Clinician Access

Unlimited asynchronous messaging with your care team. Most messages answered within 24 hours. 24/7 support line for urgent concerns.

Section 3

The Science

How GLP-1 Works

Glucagon-like peptide-1 (GLP-1) is a hormone naturally produced in the gut after eating. It stimulates insulin release in a glucose-dependent manner, suppresses glucagon, slows gastric emptying, and — critically — acts on brain receptors to reduce appetite and what researchers call "food noise." GLP-1 receptor agonist medications extend these effects for days rather than minutes.

The SURMOUNT-1 trial demonstrated that tirzepatide produced an average body weight reduction of 20.9% over 72 weeks. The SELECT trial (semaglutide, 2023) showed a 20% reduction in major adverse cardiovascular events independent of weight loss — establishing GLP-1 agonists as cardiovascular medications, not merely weight loss drugs.

Potential Side Effects

The most common side effects are gastrointestinal: nausea, constipation, and reduced appetite. These are dose-dependent and typically diminish as the body adapts. Titrating the dose slowly — which your clinician will manage — substantially reduces the incidence and severity.

  • Nausea (most common, especially at initiation): 30–44% of patients, typically resolves within 4–8 weeks
  • Constipation: 24% of patients; responsive to fiber and hydration
  • Vomiting: 16% of patients at higher doses; managed by slower titration
  • Rare but serious: pancreatitis, gallbladder disease — your clinician will screen for risk factors

Expected Timeline & Outcomes

Weeks 1–4Titration phase. Dose adjusted upward gradually. Most patients experience reduced appetite by week 3.
Months 1–3Active loss phase. Average weight reduction of 4–7% of body weight in the first 12 weeks at therapeutic dose.
Months 3–12Sustained loss and metabolic improvement. Most clinical outcomes (HbA1c, blood pressure, lipids) improve in this window.
12+ MonthsMaintenance or taper. Your clinician determines whether to continue, reduce dose, or transition to a maintenance plan.

Section 4

Pricing & Timeline

Compound injections

from $249/mo

Compound oral formulations

from $279/mo

Branded (Ozempic / Zepbound)

from $1,299/mo

Typical program duration: 6–12 months minimum for meaningful, sustained outcomes

Your clinician will recommend a timeline based on your response and progress

Labs, clinician consultations, and support are included — no separate billing

No insurance required. Cash-pay. No prior authorizations or claim denials.

When you reach your clinical goals

Your clinician will transition you to a maintenance plan — a lower-dose or lower-frequency protocol designed to preserve your results. The goal of this program is a sustainable metabolic improvement, not indefinite medication dependency.

Ready to proceed?

Your Next Step

Compounded Medication Disclosure

Compounded medications are prepared by a licensed compounding pharmacy and are NOT approved by the U.S. Food and Drug Administration. They are dispensed only pursuant to a prescription from a licensed clinician who has determined the treatment is appropriate for you. Not all patients will qualify. Side effects are possible; your clinician will review your health history with you. Medication options and availability may change at any time without notice. This information is educational and is not a substitute for individualized medical advice.

Before you go further

See if this program is right for you

Two details — your name and email — and you'll see the price and what happens next. The medical questions are asked once, by the clinician who acts on them. Not everyone qualifies, and they'll tell you honestly.

From $249/mo

Charged when you complete intake. Full refund if a clinician decides it isn't right for you.

The Enough! Health Ecosystem

One connected system

Wellness, insurance, and group coverage — separately available, designed to work together.

GLP-1 medications require a clinician assessment and prescription. Not all patients will qualify. Compound medications are not FDA-approved but are prepared by licensed pharmacies under applicable regulations. Enough! Health Wellness services are provided through our licensed clinical partner network. 18+ only.