Home/Programs/GLP-1 Metabolic Program
GLP-1 · Semaglutide · Tirzepatide

The weight management program
that starts with your health, not a prescription.

Clinician-supervised metabolic program — labs included, full titration support, and ongoing care. Compound semaglutide and tirzepatide from $249/month. No prior authorization. No insurance required.

Section 1

Is This Program Right For You?

This program is designed for people who:

  • Have a BMI of 27 or higher, or BMI 25+ with a weight-related health condition (hypertension, type 2 diabetes, sleep apnea)
  • Have struggled with sustained weight loss through diet and exercise alone
  • Want clinician-supervised support for insulin resistance or metabolic syndrome
  • Are seeking cardiovascular risk reduction alongside weight management
  • Are adults aged 18–74 in any U.S. state

This program may NOT be appropriate if:

  • You have a personal or family history of medullary thyroid carcinoma (MTC) or MEN2 syndrome
  • You have a history of pancreatitis
  • You are pregnant, planning pregnancy, or breastfeeding
  • You have severe gastrointestinal disease
  • You have type 1 diabetes or a history of diabetic ketoacidosis

Your clinician will make the final determination during your consultation. The criteria above are guidelines, not absolutes.

Section 2

What's Included

🩺

Clinician Consultation

Initial evaluation of your health history, goals, and contraindications. Monthly async check-ins to assess response and adjust your protocol.

🔬

Lab Work & Monitoring

Baseline labs ordered at start. Quarterly monitoring of relevant metabolic markers. Your clinician reviews results and adjusts accordingly.

💊

Medication (If Prescribed)

Compound semaglutide or tirzepatide — injections or oral formulations — prescribed only if your clinician determines it's clinically appropriate.

📋

Lifestyle Support Plan

Nutrition principles, movement guidelines, and sleep protocols tailored to support and extend GLP-1 outcomes — designed by your care team.

📈

Progress Tracking

Monthly weight, energy, and symptom check-ins via the patient portal. Lab trends visualized over time so you can see what's working.

💬

Ongoing Clinician Access

Unlimited asynchronous messaging with your care team. Most messages answered within 24 hours. 24/7 support line for urgent concerns.

Section 3

The Science

How GLP-1 Works

Glucagon-like peptide-1 (GLP-1) is a hormone naturally produced in the gut after eating. It stimulates insulin release in a glucose-dependent manner, suppresses glucagon, slows gastric emptying, and — critically — acts on brain receptors to reduce appetite and what researchers call "food noise." GLP-1 receptor agonist medications extend these effects for days rather than minutes.

The SURMOUNT-1 trial demonstrated that tirzepatide produced an average body weight reduction of 20.9% over 72 weeks. The SELECT trial (semaglutide, 2023) showed a 20% reduction in major adverse cardiovascular events independent of weight loss — establishing GLP-1 agonists as cardiovascular medications, not merely weight loss drugs.

Potential Side Effects

The most common side effects are gastrointestinal: nausea, constipation, and reduced appetite. These are dose-dependent and typically diminish as the body adapts. Titrating the dose slowly — which your clinician will manage — substantially reduces the incidence and severity.

  • Nausea (most common, especially at initiation): 30–44% of patients, typically resolves within 4–8 weeks
  • Constipation: 24% of patients; responsive to fiber and hydration
  • Vomiting: 16% of patients at higher doses; managed by slower titration
  • Rare but serious: pancreatitis, gallbladder disease — your clinician will screen for risk factors

Expected Timeline & Outcomes

Weeks 1–4Titration phase. Dose adjusted upward gradually. Most patients experience reduced appetite by week 3.
Months 1–3Active loss phase. Average weight reduction of 4–7% of body weight in the first 12 weeks at therapeutic dose.
Months 3–12Sustained loss and metabolic improvement. Most clinical outcomes (HbA1c, blood pressure, lipids) improve in this window.
12+ MonthsMaintenance or taper. Your clinician determines whether to continue, reduce dose, or transition to a maintenance plan.

Section 4

Pricing & Timeline

Compound injections

from $249/mo

Compound oral formulations

from $279/mo

Branded (Ozempic / Zepbound)

from $1,299/mo

Typical program duration: 6–12 months minimum for meaningful, sustained outcomes

Your clinician will recommend a timeline based on your response and progress

Labs, clinician consultations, and support are included — no separate billing

No insurance required. Cash-pay. No prior authorizations or claim denials.

When you reach your clinical goals

Your clinician will transition you to a maintenance plan — a lower-dose or lower-frequency protocol designed to preserve your results. The goal of this program is a sustainable metabolic improvement, not indefinite medication dependency.

Ready to proceed?

Your Next Step

Compounded Medication Disclosure

Compounded medications are prepared by a licensed compounding pharmacy and are NOT approved by the U.S. Food and Drug Administration. They are dispensed only pursuant to a prescription from a licensed clinician who has determined the treatment is appropriate for you. Not all patients will qualify. Side effects are possible; your clinician will review your health history with you. Medication options and availability may change at any time without notice. This information is educational and is not a substitute for individualized medical advice.

The Enough! Health Ecosystem

One connected system

Wellness, insurance, and group coverage — separately available, designed to work together.

GLP-1 medications require a clinician assessment and prescription. Not all patients will qualify. Compound medications are not FDA-approved but are prepared by licensed pharmacies under applicable regulations. Enough! Health Wellness services are provided through our licensed clinical partner network. 18+ only.